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ARTham Therapeutics Presents Preclinical Data from Its Clinical NASH Candidate ART-648 at The International Liver Congress

YOKOHAMA, February 12, 2019 – ARTham Therapeutics, Inc., a clinical stage biopharmaceutical company that will deliver “medicines that matter” for patients, will present preclinical data on ART-648, an investigational phosphodiesterase type 4 (PDE4) inhibitor in a poster session at the European Association for the Study of the Liver, The International Liver Congress (ILC 2019), taking place in Vienna, Austria, April 10-14, 2019. ART-648 is a first-in-mechanism, orally-available, selective and potent inhibitor of PDE4 in development for the treatment of non-alcoholic steatohepatitis (NASH). Details of the poster presentations are as follows:
Title: Anti-metabolic, anti-inflammatory and anti-fibrotic properties of ART-648, a novel phosphodiesterase 4 inhibitor as a potential clinical candidate for non-alcoholic steatohepatitis
Location: Reed Messe Wien Congress and Exhibition Center, Vienna, Austria
Date & Time: Saturday, April 13, 9:00 – 17:00



About NASH
NASH is a progressive form of non-alcoholic fatty liver disease (NAFLD) with patients that advance to fibrosis due to inflammatory processes that result into cirrhosis or liver cancer. NASH is expected to be the most frequent reason for liver transplant by 2020. There is no approved pharmacotherapy for NASH. Although it is difficult to obtain an accurate estimate of NASH prevalence given the fact that NASH is a silent disease, there is a report that the global prevalence of NAFLD is as high as one billion. In the United States, NAFLD is estimated to be the most common cause of chronic liver disease, affecting between 80 and 100 million individuals, among whom nearly 25% progress to NASH (World J Gastroenterol 2017, 23: 8263-8276).


About ART-648
ART-648 is a first-in-mechanism, small molecule inhibitor of PDE4 in development to treat NASH. ART-648 potently and selectively inhibits PDE4 enzyme and is shown its direct anti-inflammatory, anti-metabolic- and anti-fibrotic via cAMP elevation in multiple disease relevant in vitro and in vivo models. ART-648 possesses superior physico-chemical properties combined with clinical and safety data analyses indicating tolerability profile similar or better to marketed PDE4 inhibitors. Ph1 clinical trial is currently being conducted in Japan, entering Phase 2a in 2H2019.


About ARTham Therapeutics
ARTham Therapeutics is a clinical stage biopharmaceutical company that will deliver “medicines that matter” for patients, with a compelling portfolio developed through unraveling hidden value of existing pharma assets. ARTham is a virtual R&D company that seeks the best academic and business partners to rapidly develop high value clinical candidates. The company is headquartered in Yokohama, Japan. For more information, please visit


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